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Elderly or debilitated patients seem to tolerate GI ulcerations and bleeding less well than other individuals taking NSAIDs (see WARNINGS, RISK of GI Ulceration, Bleeding And Perforation With NSAID Therapy). The risk or severity of adverse effects can be increased when Leflunomide is combined with Benoxaprofen. It is used topically, and is primarily effective against Gram-positive bacteria. RABEPRAZOLE prevents the production of acid in the stomach. Patent 3,660,577; May 2,1972; and U. These antacids can make azithromycin less effective when taken at the same time.