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Duration of therapy: When given as the sole diuretic, continue the initial dose for at least 5 days, after which the initial dose may be adjusted to an optimal maintenance dose. Peak/trough ratio of Cardura XL is less than half that of immediate release Cardura tablets. Talk to your doctor about the risks of taking finasteride. The risk or severity of adverse effects can be increased when Stepronin is combined with Leflunomide. Some properties of angiotensin converting enzyme in the lung in vivo". Sometimes people may develop flushing, sweats or palpitations when taking this drug but these effects are usually related to taking too much thyroxine rather than being due to an intrinsic harmful side-effect.