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The safety and efficacy in children (newborn to 18 years of age) with HE have not been established. The metabolism of Phenytoin can be increased when combined with Fosphenytoin. Two recent reviews found that trazodone is the second most prescribed agent for insomnia, but as most studies have been limited to people with depression, few studies actually support trazodone's use in primary insomnia. The risk or severity of adverse effects can be increased when Buspirone is combined with Ethosuximide. The secretory epithelium is mainly pseudostratified, comprising tall columnar cells and basal cells which are supported by a fibroelastic stroma - containing randomly oriented smooth-muscle bundles - that's continuous with the bladder. Chlorpromazine may increase the QTc-prolonging activities of Haloperidol.